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Notice peek

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NE
TenderFTS · 06ae08

Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service

NHS England
Closes in
29d
08 Jul 2026
Estimated
£26.1m
Services
Published
04 Jun 2026

Key facts

Notice ID
ocds-h6vhtk-06ae08
CPV code
85100000 · Health & social
Contract type
services
Source
Find a Tender

Timeline

  1. Published
    04 Jun 2026
  2. Submission deadline
    08 Jul 2026 · 29 days from now

Description

Onasemnogene abeparvovec intravenous (Zolgensma®) is a one-time, in vivo gene replacement therapy, for use in babies aged 12 months and under, that utilises an adeno-associated virus serotype 9 (AAV9) vector, modified to contain a functional copy of the human SMN1 gene. It is administered intravenously, allowing the vector to deliver the gene into motor neurones and peripheral tissues, enabling the sustained expression of survival motor neuron (SMN) protein, which is deficient or mutated in individuals with SMA.<br/><br/>Onasemnogene abeparvovec intrathecal (OAV101 IT) is a one-time in vivo gene replacement therapy for patients with SMA, proposed to treat individuals with SMA aged 2 years and over. This intrathecal injection will be used to treat a distinct cohort of SMA patients to Zolgensma. It will be assessed via NICE’s technology appraisal programme, with an expected final guidance publication date in late 2026.

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