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Type

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Notice

CLOSED

05 Mar

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Estimated

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Bournemouth and Poole College

CA17034 - Bournemouth & Poole College - Audio Visual Equipment and Services

Radio & TV equipment· Published 19 Jan

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ClosedCF · 3a1ab9c5faf2

Biological Services- Models Cryopreservation of MHRA Breeding Stock

Medicines and Healthcare Products Regulatory Agency

Status

Closed

Estimated

—

Published

27 Jan 2025

Key facts

Notice ID: cf-a362d686-4f05-4332-b56b-3a1ab9c5faf2
CPV code: 71900000 · Architecture & engineering
Source: Contracts Finder

Timeline

Published
27 Jan 2025

Description

Tenders are invited from establishments who have the capabilities to take on all services related to transgenic colony management. At the MHRA, the Biological Services facility houses two transgenic mouse breeding colonies. These colonies have been specifically bred to support the Poliomyelitis test work implemented by the Science, Research & Innovation Group. In-bred transgenic mice with the Human Polio receptor gene provides a practical alternative to the use of non-human primates. These lines are used to assess the neurovirulence of polioviruses and immunogenicity/ protection of vaccines and hence play a key role in the global polio activities of the Agency. Both colonies require refresh, as genetic drift has been observed due to multiple unexpected phenotypic changes. We are therefore seeking assistance in the maintenance and refresh of colonies, possibly looking to utilise already frozen stocks of embryos/ sperm.