NHSBT1202 - BBMR Stem Cell Services

The British Bone Marrow Registry (BBMR) is a division of NHS Blood and Transplant. The Northern Ireland and Scottish Blood Transfusion Services are participants in the service provided by the BBMR. The BBMR supports HSC Clinical Transplantation Programmes for UK and International patients. It recruits prospective stem cell donors from the blood donor population. The donors are tissue typed and they are then available to be searched by accredited Transplant Centres or laboratories acting on their behalf for patients with leukaemia and other blood disorders. After further identification testing a donor may be selected as the final donor. The BBMR collects HSC products from donors between the ages of 18 and 60. The finally selected donor is counselled and informed consent for the donation obtained. Donor counselling is currently performed by the BBMR in accordance with Human Tissue Authority (HTA) and World Marrow Donor Association (WMDA) requirements. Responsibility for this service can be undertaken by the service provider. The donor must be medically assessed and fitness to donate the HSC product determined. The medical assessment of the donor includes the risk of disease transmission to the recipient. The source of stem cells for First and Subsequent donations is from the Bone Marrow under General Anaesthetic (GA) as an inpatient, or Peripheral Blood stimulated by Granulocyte Colony Stimulating Factor (G-CSF) as an outpatient procedure. Subsequent donations for the same patient may also include blood lymphocytes. For a peripheral blood stem cell collection donors receive a short course of G-CSF, 4 or 5 days. The successful bid service provider will prescribe G-CSF as Lenograstim, Granocyte®. BBMR require a Collection Centre, located in the Central London area The service provider will procure, label and issue the HSC product, for distribution under direction from BBMR. .