Circular dichroism spectrophotometer

The Royal Botanic Gardens, Kew ("RBGKEW") is undertaking early market engagement to test the clarity of our stated requirements and the availability of solutions to meet these requirements. To determine the absolute structure of pure natural products isolated from plants and fungi at RBG Kew for which the relative structure has been determined by nuclear magnetic resonance (NMR) spectroscopy. RBG Kew anticipates that the solution to this requirement is likely to be by chiroptical spectroscopic methods; however, as the compound may be new-to-science, no reference compound of known chirality will be available. The solution proposed must be applicable to the quantity of pure compound typically isolated for NMR spectroscopy at RBG Kew and, in most cases where the sample is in limited quantity, the sample used for NMR will be that presented to the absolute configuration workflow i.e. initially be in the deuterated solvent with TMS reference used for NMR. For compounds with multiple chiral centres, the NMR determination may have reduced the number of possibilities for the absolute structure. The requirement includes any molecular modelling techniques required to arrive at the absolute structure from the experimental data, be these your own proprietary methods/third-party or open access modelling software. For further information about this early market engagement including the specification, and an early market engagement form please contact Jamal Jimenez (j.jimenez@kew.org).